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USP10, Active
USP10, Active
- 中文名称：
- USP10, Active
- 英文名称：
- USP10, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA74099
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human USP10 (154-798) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The USP10 gene accession number is NM_005153.
Ubiquitin specific protease 10 (USP10) is a member of the ubiquitin specific protease family of cysteine proteases. It is ubiquitously expressed in many cell lines and knock out of USP10 in mice results in bone marrow failure and death within one year. (1) USP 10 acts as an antistress under conditions such as oxidative stress, heat shock and viral infection. (2) It has been associated with cancer and known to stabilize the tumor suppressor p53 and SIRT6. (3) USP10 also inhibits ubiquitinated protein-induced apoptosis by interacting with ubiquitin receptor p62 and promoting aggresome formation thereby cooperatively inhibiting apoptosis. (1)
