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PERK Positive Control
PERK Positive Control
- 中文名称：
- PERK Positive Control
- 英文名称：
- PERK Positive Control
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA75976
- 规格：
- 5 Applications|2x5 Applications|3x5 Applications|4x5 Applications|5x5 Applications
- 保存建议：
- Store at -20°C for long term storage
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Western Blot Positive Control in ready to use SDS-sample buffer
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Western Blot Positive Control Eukaryotic translation initiation factor 2-alpha kinase 3
Overview: Protein kinase- Eukaryotic translation initiation tactor 2-a kinase 3 (PERK) is a SerinelThreonine protein kinase, type I membrane protein of the endoplasmic reticulum that is abundant in secretory tissues and is inducible by ER-stress. ER stress increases the activity of PERK which phosphorylates the a subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, a reduction of translation initiation and repression of global protein synthesis., which then phosphorylates elF2a to promote reduced translation (1). PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of Cyclin 01. Research studies have demonstrated that PERK-deficient mice have defects in pancreatic 13 cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS) which is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities
PERK selective antibodies were generated against a peptide taken from the human PERK protein. The PERK-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage.
