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Human CD80 Recombinant (B7-1)
Human CD80 Recombinant (B7-1)
- 中文名称：
- Human CD80 Recombinant (B7-1)
- 英文名称：
- Human CD80 Recombinant (B7-1)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76080
- 规格：
- 0.05 mg|0.2 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- Recombinant CD80, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.
Avoid repeated freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >90%, as determined by SDS-PAGE and HPLC
- 产品形式：
- Recombinant CD80 was lyophilized from 0.2um filtered 50mM Tris, 100mM NaCl, pH 8.0.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
CD80 is a monomeric surface protein found on activated APCs. The extracellular region of CD80 consists of two highly glycosylated Ig- like extracellular domains, which have defined regions for binding its ligands, CD28 or CTLA-4, on T cells.One ligand of CD80, CD28, provides critical costimulatory signals to activated T cells to increase cytokine production, cell proliferation, and cell viability, while the other ligand, CTLA-4, may mediate a growth-inhibitory signal.The same regions of CD80 are involved in binding to both CD28 and CTLA-4, but CTLA-4 binds to CD80 with about a 20-fold higher avidity than CD28 does. This suggests that low levels of CTLA-4 expressed on the cell surface can compete for CD80 binding even when CD28 is expressed at much higher levels.
