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Human IL-13 alpha 2 receptor Recombinant (IL13RA2)
Human IL-13 alpha 2 receptor Recombinant (IL13RA2)
- 中文名称：
- Human IL-13 alpha 2 receptor Recombinant (IL13RA2)
- 英文名称：
- Human IL-13 alpha 2 receptor Recombinant (IL13RA2)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76103
- 规格：
- 0.02 mg|0.1 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Recombinant IL13RA2, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.
Avoid repeated freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >98%, as determined by SDS-PAGE and HPLC
- 产品形式：
- Recombinant IL-13 receptor alpha 2 is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
The biological activity of IL-13 is regulated via the IL-13R type I and type II. The type I receptor is a heterodimer of the IL-4R α chain (IL-4Rα) and IL-13Rα1, and ligand-receptor interactions induce phosphorylation of the IL- 4Rα and subsequent activation of the signal transducers and activators of transcription (STAT) -6 signaling pathway. This pathway appears to be the primary pathway for IL-13- induced signaling in nonhematopoietic cells. The type II receptor is composed of IL-13Rα1 and IL-13Rα2. IL-13Rα2 binds IL-13 with high affinity and is proposed to act as a decoy receptor that limits the activity of IL-13. Consistent with this, mice deficient in IL-13Rα2 demonstrate exaggerated IL- 13-induced pathologies. IL- 13Rα2 possesses a short cytoplasmic tail and is without signal motifs; however, there have been a number of reports to suggest IL-13 signals through this chain, possibly via a STAT6- independent, AP-1-dependent manner to induce activation of the Tgfβ1 promoter via the IL-13 type II receptor.
