-
Human IL-12 receptor beta 1 Recombinant
Human IL-12 receptor beta 1 Recombinant
- 中文名称：
- Human IL-12 receptor beta 1 Recombinant
- 英文名称：
- Human IL-12 receptor beta 1 Recombinant
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76114
- 规格：
- 0.005 mg|0.025 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- The lyophilized protein is stable for at least 2 years from date of receipt at -20°C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2°C to 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >95%, as determined by SDS-PAGE and HPLC
- 产品形式：
- Recombinant Human Interleukin-12 receptor beta was lyophilized from a 0.2 um filtered PBS solution pH 7.4.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X- linked inheritance
