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Recombinant human CTLA-4 protein with C-terminal human Fc tag
Recombinant human CTLA-4 protein with C-terminal human Fc tag
- 中文名称：
- Recombinant human CTLA-4 protein with C-terminal human Fc tag
- 英文名称：
- Recombinant human CTLA-4 protein with C-terminal human Fc tag
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78604
- 规格：
- 0.05 mg|2x0.05 mg|3x0.05 mg|4x0.05 mg|5x0.05 mg
- 保存建议：
- Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
- 货期：
- 6-8周
- 纯度：
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- 产品形式：
- Lyophilized from sterile PBS, pH7.4. Normally 5 %-8% trehalose is added as protectants before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
The protein has a predicted molecular mass of 39.6 kDa after removal of the signal peptide. The apparent molecular mass of CTLA4-hFC is approximately 40-55 kDa due to glycosylation. This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
