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Human PlGF-2
Human PlGF-2
- 中文名称：
- Human PlGF-2
- 英文名称：
- Human PlGF-2
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79127
- 规格：
- 0.005 mg|2x0.005 mg|3x0.005 mg|4x0.005 mg|5x0.005 mg
- 保存建议：
| Product Form | Temperature | Storage Time |
| Lyophilized | -20°C to -80°C | 1 year |
| Lyophilized | 2°C to 8°C | 6 months |
| Lyophilized | Room Temperature | 1 month |
| Reconstituted | 2°C to 8°C | 1 week |
| Extended Storage | -20°C to -80°C | 3 months |
Avoid repeated freeze/thaw cycles
- 货期：
- 6-8周
- 纯度：
- > 95% by SDS-PAGE & silver stain
- 产品形式：
- Sterile filtered protein solution was lyophilized from 50 mM acetic acid; contains 50x BSA stabilizer
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Human Placenta Growth Factor-2 (PlGF-2), a 22 kDa protein consisting of 152 amino acid residues is produced as a homodimer. PlGF is a polypeptide growth factor and a member of the platelet-derived growth factor family but more related to vascular endothelial growth factor (VEGF). PlGF acts only as a weak mitogen for those cell types possessing receptors for binding (e.g. vascular endothelial cells). At least one high-affinity receptor for PlGF (FLT-1 or VEGF-R1) has been demonstrated in different primary cell types (e.g. human umbilical vein endothelial cells and monocytes). In addition to its action as a weak mitogen it is also a chemoattractant for monocytes and endothelial cells. Two different proteins are generated by differential splicing of the human PlGF gene: PlGF-1 (131 aa native chain) and PlGF-2 (152 aa native chain). Both mitogens are secretable proteins, but PlGF-2 can bind to heparin with high affinity. PlGF is apparently a homodimer, but preparations of PlGF show some heterogeneity on SDS gels depending of the varying degrees of glycosylation. All dimeric forms possess similar biological activities. If PlGF is angiogenic in vivo is not clear. However, heterodimers between VEGF and PlGF are mitogenic for endothelial cells and have strong angiogenic activity in vivo (e.g. in the CAM assay or in the cornea pocket assay). Different cells and tissues (e.g. placenta) express PlGF-1 and PlGF-2 at different rates. A much related protein of PlGF is VEGF with about 53% homology and VEGF-B with similar biological activities.
