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Human Galectin-1
Human Galectin-1
- 中文名称：
- Human Galectin-1
- 英文名称：
- Human Galectin-1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79150
- 规格：
- 0.05 mg|2x0.05 mg|3x0.05 mg|4x0.05 mg|5x0.05 mg
- 保存建议：
- The lyophilized human Galectin-l, though stable at room temperature, is best stored desiccated below O degree C. Reconstituted human Galectin-I should be stored in working aliquots at -20 degree C . Avoid repeated freeze and thaw cycles!
- 货期：
- 6-8周
- 纯度：
- >98% by SDS-PAGE & Coomassie stain
- 产品形式：
- lyophilized
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Lectins, of either plant or animal ongm, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. Galectin-I (Gal-I) is one of 15 evolutionarily conserved 13-galactoside-binding proteins that display biologicallydiverse activities in pathogenesis of inflammation and cancer. Gal-I is variably expressed on immune cells and endothelial cells, though is commonly found and secreted at high levels in cancer cells. There is also compelling evidence in models of cancer and autoimmunity that recombinant Gal-I (rGal-l) can potentiate immunoregulatory function of T cells. Galectin-I is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-Ieukemia cell lines through homodimeric binding of Nacetyllactosamines on membrane glycoproteins (Gal-l ligands) and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-l is a 14.5 kDa protein containing 134 amino acid residues.
