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Human Heregulin beta-1
Human Heregulin beta-1
- 中文名称：
- Human Heregulin beta-1
- 英文名称：
- Human Heregulin beta-1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79196
- 规格：
- 0.01 mg|0.05 mg|2x0.05 mg|3x0.05 mg|4x0.05 mg
- 保存建议：
- The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2-8°C and for 12 months at -20°C to -80°C.
- 货期：
- 6-8周
- 纯度：
- > 98% by SDS-PAGE and HPLC analysis
- 产品形式：
- Lyophilized
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-beta1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-beta1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-beta1 (HRG1-beta1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-beta1 (65 amino acid residues).
