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Human ApoE2
Human ApoE2
- 中文名称：
- Human ApoE2
- 英文名称：
- Human ApoE2
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79218
- 规格：
- 0.1 mg|0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg
- 保存建议：
- The lyophilized protein is stable at room temperature for 1 month and at 4 degrees C for 6 months. Reconstituted working aliquots are stable for 1 week at 2 degrees C to 8 degrees C and for 3 months at -20 degrees C to -80 degrees C. Avoid repeated freeze and thaw cycles.
- 货期：
- 6-8周
- 纯度：
- > 90% by SDS-PAGE and HPLC analyses
- 产品形式：
- Lyophilized; 20 mM Sodium Phosphate, pH 7.8 + 0.5 mM DTT
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.
