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Human Wnt-7a
Human Wnt-7a
- 中文名称：
- Human Wnt-7a
- 英文名称：
- Human Wnt-7a
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79230
- 规格：
- 0.003 mg|0.015 mg|2x0.015 mg|3x0.015 mg|4x0.015 mg
- 保存建议：
- The lyophilized protein is stable at room temperature for 1 month and at 4°C for 3 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 3 months at -20°C to -80°C.
- 货期：
- 6-8周
- 纯度：
- >80% by SDS-PAGE & HPLC analysis
- 产品形式：
- Lyophilized from 10mM Sodium Phosphate, pH7.5 + 500mM NaCl + 0.5% CHAPS
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of beta-Catenein degradation. Intracellular accumulation of ï¢-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/beta-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions
