-
Mouse Adiponectin (Acrp30)
Mouse Adiponectin (Acrp30)
- 中文名称：
- Mouse Adiponectin (Acrp30)
- 英文名称：
- Mouse Adiponectin (Acrp30)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79239
- 规格：
- 0.005 mg|0.025 mg|2x0.025 mg|3x0.025 mg|4x0.025 mg
- 保存建议：
- The lyophilized is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 3 months at -20° to -80°C.
- 货期：
- 6-8周
- 纯度：
- > 98% by SDS-PAGE gel and HPLC analyses.
- 产品形式：
- Lyophilized; 20 mM Tris, pH 8.5 + 75mM L-Arginine.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Adiponectin is an adipose-derived secreted protein containing 236 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-beta and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Val-21 to Asn-247 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 31-36 kDa by SDS PAGE analysis under reducing conditions.
