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Mouse GDNF
Mouse GDNF
- 中文名称：
- Mouse GDNF
- 英文名称：
- Mouse GDNF
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79245
- 规格：
- 0.002 mg|0.01 mg|2x0.01 mg|3x0.01 mg|4x0.01 mg
- 保存建议：
- The lyophilized protein is stable at 4°C. Reconstituted working aliquots are stable at 2°C to 8°C and -20°C to -80°C.
- 货期：
- 6-8周
- 纯度：
- > 98% by SDS-PAGE and HPLC analyses
- 产品形式：
- Lyophilized (10mM Sodium Cirate)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
