Human VEGF165-Human VEGF165-蛋白质检测试剂 - 北京博蕾德生物科技有限公司

中文名称：

Human VEGF165

英文名称：

Human VEGF165

品牌：

AAA Biotech

品牌介绍：

AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。

货号：

AAA79288

规格：

0.02 mg|2x0.02 mg|3x0.02 mg|4x0.02 mg|5x0.02 mg

保存建议：

After initial reconstitution, the addition of at least 0.1% human or bovine serum albumin is recommended for frozen aliquots. Prepare and store working aliquots at -20°C to -80°C.

Product Form	Temperature	Storage Time
Lyophilized	-20°C to -80°C	1 year
Lyophilized	2°C to 8°C	6 months
Lyophilized	Room Temperature	1 month
Extended Storage	-20°C to -80°C	3 months

货期：: 6-8周

纯度：: > 95% by SDS-PAGE & silver stain

产品形式：: Sterile filtered protein solution was lyophilized from 50 mM acetic acid, free from stabilizers and preservatives.

免责声明：: *本产品仅供科研实验使用，不得用于临床诊断。*

说明书：

Human Vascular Endothelial Growth Factor VEGF165, a 23 kDa protein consisting of 165 amino acid residues, is produced as a homodimer. VEGF is a polypeptide growth factor and a member of the platelet-derived growth factor family. It is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. Two high-affinity tyrosine kinase receptors for VEGF165 have been identified, VEGFR-1 (FLT-1), and VEGFR-2 (KDR). Consistent with the endothelial cell-specific action of VEGF165, expression of both receptor genes has been found predominantly but not exclusively on endothelial cells. Expression of VEGFR-1 was also found on human monocytes, neutrophils (PMNs), bovine brain pericytes and villous and extra villous trophoblast. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo. VEGF165 is also a chemo attractant molecule for monocytes and endothelial cells. 5 different proteins are generated by differential splicing: VEGF121, VEGF145, VEGF165, VEGF189 and VEGF206. The most abundant form is VEGF165. Whereas VEGF121 and VEGF165 are secreted proteins, VEGF145, VEGF189 and VEGF206 are strongly cell-associated. The isoforms VEGF145, VEGF165 and VEGF189 bind to heparin with high affinity. VEGF165 is apparently a homo-dimer, but preparations of VEGF165 show some heterogeneity on SDS gels, depending on the secretion of different glycosylation patterns. All dimeric forms have similar biological activities but their bioavailability is very different. There is good evidence that different cells and tissues express different VEGF isoforms. The other members of this increasing growth factor family are VEGF-B, -C, -D and -E. Another member is the Placenta growth factor PlGF.

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