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Human LDH (Plasmodium falciparum)
Human LDH (Plasmodium falciparum)
- 中文名称：
- Human LDH (Plasmodium falciparum)
- 英文名称：
- Human LDH (Plasmodium falciparum)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79327
- 规格：
- 5x0.025 mg
- 保存建议：
- According to the available data the liquid protein stored at 4-8°C is stable at least for about 10 months.
Avoid repeated freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- ~71% by SDS-PAGE & Coomassie bluestaining
- 产品形式：
- Liquid; 50 mM Tris, 250 mM NaCl, 1 mM EDTA, pH8.0
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Malaria is one of the most widespread infectious diseases affecting some 500 million people with an enormous cost in human suffering and economic hardship. Effective treatment of the disease is increasingly compromised by rising resistance of malaria parasites to currently available anti-malarials. The parasites are homolactate fermenters and rely on glycolysis for energy generation since the parasites appear to lack a functional citric acid cycle. The NAD+ consumed during glycolysis is reduced to NADH by lactate which, in turn, is oxidized to pyruvate. This reaction is catalyzed by lactate dehydrogenase (LDH). It has been demonstrated that inhibitors of this enzyme have parasiticidal activity. Since LDH from the malaria parasite Plasmodium falciparum (PfLDH) has notable structural and kinetic differences from human LDHs, the enzyme appears to be an attractive target for novel anti-malarial therapeutics. The parasite, P. falciparum, is the most lethal of malarial plasmodia being responsible for the cerebral form of the disease; consequently it has been the major focus of initial biochemical and genomic investigation. On the other hand, the parasite P. vivax is of great importance as it is the most widespread and common of the malarial plasmodia and, therefore, is responsible for the greatest burden of disease.
