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Human ACE-2
Human ACE-2
- 中文名称：
- Human ACE-2
- 英文名称：
- Human ACE-2
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79329
- 规格：
- 0.005 mg|0.02 mg|2x0.02 mg|3x0.02 mg|4x0.02 mg
- 保存建议：
- 请按照说明书指示
- 货期：
- 6-8周
- 纯度：
- > 95% by SDS-PAGE & Coomassie stain
- 产品形式：
- lyophilized
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Angiotensin I Converting Enzyme (ACE2) is a dimeric, zinc-dependent metalloprotease of the ACE family. ACE2 has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 is abundantly expressed in a variety of cells residing in many different human organs. In human physiology, ACE2 is a pivotal counter-regulatory enzyme to ACE by the breakdown of angiotensin II, the central player in the renin-angiotensin-aldosterone system (RAAS) and the main substrate of ACE2. Full length ACE2 protein includes an extracellular region composed of a single N-terminal peptidase domain and C-terminal collectrin-like domain (CLD), a transmembrane domain, and a short cytoplasmic tail. The N-terminal peptidase region is required for binding to SARS-CoV and SARS-CoV2 spike proteins, while the CLD contains a region that promotes dimerization and association with amino acid transporters. The peptidase domain contains a long deep cleft that undergoes a large hinge-bending movement at substrate and inhibitor binding. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE2 activity and inhibitors of ACE2 do not inhibit ACE activity. The recombinant sACE2 consists of the extracellular domain from Gln18 to Asn639 and was fused at the C terminus to the human Fc-tag.
