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Anti-Shank1 Antibody
Anti-Shank1 Antibody
- 中文名称：
- Anti-Shank1 Antibody
- 英文名称：
- Anti-Shank1 Antibody
- 品牌：
- NeuroMab
- 品牌介绍：
- NeuroMab是美国国立卫生研究院神经单抗研究所成立于2004年，旨在生产可用于神经学研究的小鼠单克隆抗体。这些抗体广泛应用于动物脑组织样本检测，包括免疫印迹、免疫组化等。引用NeuroMab的产品发表的文献，已超过：3300篇。
- 货号：
- 75-064
- 规格：
- 100 µL
- 保存建议：
- Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
- 背景资料：
- SH3 and multiple ankyrin repeat domains protein 1, or shank 1 is a member of the shank family. Shank 1 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Unlike other shank family proteins, shank 1 is found in only in brain in the neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum, amygdala, substantia nigra and thalamus. Cellularly, shank 1 can be found in cytoplasm, cell junctions, postsynaptic cell membrane and postsynaptic density. Many isoforms of shank 1 exist, and some are expressed during development, while others are expressed in mature tissue. Shank 1 acts as a scaffold protein anchoring and connecting membrane bound receptors and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 1 may play a role in synapse formation and dendritic spine maturation. Mutations in this gene have been associated with autism spectrm disorder and diabetic encephalopathy.
- 货期：
- 4-6周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, and Rat
- 应用：
- WB, IHC, ICC, ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Our Anti-Shank1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N22/21. It detects human, mouse, and rat Shank1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
