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Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody
Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody
- 中文名称：
- Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody
- 英文名称：
- Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody
- 品牌：
- NeuroMab
- 品牌介绍：
- NeuroMab是美国国立卫生研究院神经单抗研究所成立于2004年，旨在生产可用于神经学研究的小鼠单克隆抗体。这些抗体广泛应用于动物脑组织样本检测，包括免疫印迹、免疫组化等。引用NeuroMab的产品发表的文献，已超过：3300篇。
- 货号：
- 75-115
- 规格：
- 100 µL
- 保存建议：
- Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
- 背景资料：
- The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).
- 货期：
- 4-6周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, and Rat
- 应用：
- WB, IHC, ICC, IP, ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Our Anti-mGluR1/5 (Group I) glutamate receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N75/3. It detects human, mouse, and rat mGluR1/5 (Group I) glutamate receptor, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
