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Anti-Tyrosine Hydroxylase (TH) Antibody
Anti-Tyrosine Hydroxylase (TH) Antibody
- 中文名称：
- Anti-Tyrosine Hydroxylase (TH) Antibody
- 英文名称：
- Anti-Tyrosine Hydroxylase (TH) Antibody
- 品牌：
- Biosensis
- 货号：
- R-148-50
- 规格：
- 50 µg
- 保存建议：
- Spin vial briefly before opening. Reconstitute in 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
- 背景资料：
- Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. FUNCTION: Plays an important role in the physiology of adrenergic neurons. CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. COFACTOR: Fe(2+) ion. ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity. PATHWAY: Catecholamine biosynthesis; first step. SUBUNIT: Homotetramer. PTM: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.
- 货期：
- 4-6周
- 来源宿主：
- Rabbit
- 应用：
- IHC-Frozen, WB
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
Our Anti-Tyrosine Hydroxylase (TH) rabbit polyclonal primary antibody detects human and rat Tyrosine Hydroxylase (TH), and is affinity-purified. It is validated for use in IHC-Frozen, WB.
