-
Recombinant human CD200 protein
Recombinant human CD200 protein
- 中文名称：
- Recombinant human CD200 protein
- 英文名称：
- Recombinant human CD200 protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA48391
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|5x0.01 mg
- 保存建议：
- Can be stored at +2C to +8 degree C for 1 week. For long term storage, aliquot and store at -20C to -80 degree C. Avoid repeated freezing and thawing cycles.
- 货期：
- 6-8周
- CAS号：
- 483-91-0
- 纯度：
- >95% by SDS-PAGE
- 属性（合成/天然）：
- 天然
- 产品形式：
- Liquid. In Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
- 分子量：
- 384.33 g/mol
- 分子式：
- C17H20O10
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
CD200, also known as OX-2 membrane glycoprotein isoform a, belongs to the immunoglobulin superfamily. This protein imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. D200 and CD200R associate via their respective N-terminal Ig-like domains. CD200-CD200R signaling have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Elevated expression of this protein has been reported to be associated with poor prognosis in a number of human malignancies. In addition, it also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion. Recombinant human CD200 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
