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Human PDGFR alpha Recombinant
Human PDGFR alpha Recombinant
- 中文名称：
- Human PDGFR alpha Recombinant
- 英文名称：
- Human PDGFR alpha Recombinant
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76058
- 规格：
- 0.02 mg|0.1 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Recombinant CD140a, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.
Avoid repeated freeze/thaw cycles.
- 货期：
- 6-8周
- CAS号：
- 760-58-7
- 纯度：
- >95%, as determined by SDS-PAGE and HPLC
- 产品形式：
- Recombinant CD140a is supplied as a 0.2 um filtered PBS solution, pH7.2.
- 分子量：
- 139.15 g/mol
- 分子式：
- C7H9NO2
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (PDGFA, PDGFB, PDGFC, and PDGFD. Ligand binding induces receptor dimerization, enabling autophosphorylation of specific tyrosine residues and subsequent recruitment of a variety of signal transduction molecules. PDGFR regulates normal cellular growth and differentiation, and expression of activated PDGFR promotes oncogenic transformation, suggesting that activating mutations or gene rearrangements could play a role in human tumorigenesis. Numerous in vitro and in vivo studies showed that inhibition of PDGFRA signaling disrupts cancer cell survival in the subset of GISTs with activating PDGFRA mutations.
