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Human Interleukin-13 Recombinant
Human Interleukin-13 Recombinant
- 中文名称：
- Human Interleukin-13 Recombinant
- 英文名称：
- Human Interleukin-13 Recombinant
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76093
- 规格：
- 0.002 mg|0.01 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
- 货期：
- 6-8周
- CAS号：
- 760-93-0
- 纯度：
- >95%, as determined by SDS-PAGE and HPLC
- 产品形式：
- Recombinant Interleukin-13 was lyophilized from a 0.2um filtered concentrated (1mg/ml) solution in PBS, pH 7.2.
- 分子量：
- 154.16 g/mol
- 分子式：
- C8H10O3
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Mouse IL13 is produced primarily by activated Th2 cells. Human IL13 is expressed in activated T- helper cells (resembling Th0, Th1, Th2), and T-cells expressing CD8. The alpha chain of the IL13 receptor has weak binding activity for IL13. High affinity receptors are formed when the receptor alpha chains of IL13 and IL4 receptors are coexpressed. The receptors for IL13 and IL4 share a component,a common gamma subunit that is found also in the IL2 receptor.Different IL13 receptor structures have been shown to exist on various cell types and the IL13 receptor may share more than one component with IL4 receptor. IL13 down-modulates macrophage activity, reducing the production of pro-inflammatory cytokines and chemokines in response to IFN-gamma or bacterial lypopolysaccharides. IL13 enhances the production of the IL1 receptor antagonist IL1ra. IL13 also decreases the production of nitric oxide by activated macrophages, leading to a decrease in parasiticidal activity. IL13 induces differentiation of human monocytes, enhances survival time in culture, and also induces differentiation and proliferation and Isotype switching in B-cells.
