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Epstein-Barr Virus EBNA1 Recombinant
Epstein-Barr Virus EBNA1 Recombinant
- 中文名称：
- Epstein-Barr Virus EBNA1 Recombinant
- 英文名称：
- Epstein-Barr Virus EBNA1 Recombinant
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76094
- 规格：
- 0.5 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- This protein can be stored in working aliquots at 2-8°C for one month, or at -20°C for six months without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
- 货期：
- 6-8周
- CAS号：
- 760-94-1
- 纯度：
- >90%
- 产品形式：
- 0.2 um filtered 50mM Tris-HCI pH 8, 10mM glutathione, 60mM NaCI, 0.25% Sarkosyl and 50% Glycerol.
- 分子量：
- 239.07 g/mol
- 分子式：
- C7H11BrO4
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
EBNA1 is the only EBV protein consistently expressed in all proliferating infected cells and plays several important roles in EBV latent infection, including the initiation of EBV DNA replication, the mitotic segregation of the EBV genomes, and transcriptional activation of other EBV latency proteins. several pieces of evidence suggest that EBNA1 plays a direct role in cellular transformation by EBV. First, EBNA1 is expressed in all EBV-associated tumors and is the only viral protein expressed in some of these tumors. Second, transgenic mice expressing EBNA1 develop malignant B cell lymphomas. Third, the expression of EBNA1 in Hodgkin cells enhances their ability to form tumors in nonobese diabetic-SCID mice. Fourth, EBV genomes lacking the EBNA1 gene are several thousand-fold less efficient at B cell immortalization than EBV genomes expressing EBNA1. Fifth, interference with EBNA1 function in Burkitt's lymphoma cells by overexpression of the EBNA1 DNA binding domain increased cell death, suggesting that EBNA1 normally provides a survival function for these cells.
