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CNP/CNPase
CNP/CNPase
- 中文名称：
- CNP/CNPase
- 英文名称：
- CNP/CNPase
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76717
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- Antibody can also be aliquotted and stored frozen at -20 degree C in a manual defrost freezer for sixmonths without detectable loss of activity. The antibody can be stored at 2 degree - 8 degree C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Goat
- 反应种属：
- Human, Mouse, Rat, Bovine, Porcine
- 应用：
- IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ICC (Immunocytochemistry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:Goat IgG
克隆号:N/A
特异性:N/A
纯度:N/A
形式：Liquid. Affinity purified antibody at 1mg/mL in 50% PBS, 50%glycerol plus 5mM NaN3
浓度：N/A
- 说明书：
The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), is an enzyme which catalyzes the hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. These cyclic nucleotides are structurally different from the better known and studied 3'5'-cyclic nucleotides of which the best known example is cyclic AMP. CNP has two isoforms, CNPase 1 (~46kDa) and CNPase 2 (~48kDa), which are encoded separately by different promoters of the same gene. These enzymes are present in very high levels in brain and peripheral nerve, makes up 4% of total CNS myelin protein. They are found almost exclusively in oligodendrocytes and Schwann cells, appearing early in oligodendrocyte development, earlier than most other myelin specific proteins. Antibodies to CNP have been very useful as a marker for these particular cell types. CNP is thought to play a critical role in the events leading up to myelination, for the oligodendrocytes overexpressing CNP appear to mature earlier in development, resulting in earlier maximum gene expression for myelin basic proteins. It has been reported that CNP is also associated with microtubules in brain tissue and may promote microtubule assembly. CNP can link tubulin to cellular membranes, and may regulate cytoplasmic microtubule distribution.
The antibody was made against the full length recombinant form of human CNP expressed in and purified from E coli, and the antibody can be used to identify myelinating cells in cell culture and in sections and to trace axonal projections in sectioned material.
