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Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody
Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody
- 中文名称：
- Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody
- 英文名称：
- Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA47750
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- IB (Immunoblot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2b
克隆号:[4F10]
特异性:IP6K2
This antibody recognizes human IP6K2.
纯度:N/A
形式：100ug in PBS, pH 7.4, purified by Protein G affinity chromatography
浓度：N/A
- 说明书：
Inositol hexakisphosphate kinase 2 (IP6K2) catalyzes the production of diphosphoinositol pentakisphosphate (IP7) and has a role as a proapoptotic gene sensitizing cancer cells to apoptosis by cell stressors and anticancer drugs all of which depend on IP6K2 catalytic activity. IP6K2 is located in the 3p21.31 chromosomal region, which often undergoes allele loss in a variety of human cancers. Some heat shock proteins, especially Hsp90, can be antiapoptotic and the targets of anticancer drugs. Hsp90 binds IP6K2 and inhibits its catalytic activity. Drugs and selective mutations that abolish HSP90-IP6K2 binding elicit activation of IP6K2, leading to cell death. Thus, the prosurvival actions of HSP90 reflect the inhibition of IP6K2, suggesting that selectively blocking this interaction could provide effective and safer modes of chemotherapy.
