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RNA Pol II CTD (pThr4) antibody
RNA Pol II CTD (pThr4) antibody
- 中文名称：
- RNA Pol II CTD (pThr4) antibody
- 英文名称：
- RNA Pol II CTD (pThr4) antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA50469
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20 degree C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8 degree C for short term use (up to 4 weeks) and store the remaining aliquots at -20 degree C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:N/A
纯度:Antiserum to human RNA pol II CTD (pThr4) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein A.
形式：Purified IgG - liquid
Phosphate buffered saline
0.035% Sodium Azide (NaN3), 30% Glycerol
浓度：N/A
- 说明书：
Rabbit anti Human RNA pol II CTD (pThr4) antibody recognizes RNA polymerase II, also known as RNAP II and pol II, when phosphorylated at threonine 4 of the carboxyl-terminal repeat domain.
RNA pol II is a 550 kDa enzyme complex made up of 12 subunits that transcribes DNA into precursors of messenger RNA (mRNA), snRNA, and microRNA (Kornburg, 1999) (Sims et al. 2004). The carboxyl-terminal repeat domain (CTD) of RNA pol II is reversibly phosphorylated in during the transcription cycle (Phatnani and Greenleaf, 2006). Phosphorylation of the CTD of RNA pol II at threonine 4 has been shown to facilitate histone mRNA 3' end processing (Hsin et al. 2011). Phosphorylation of the carboxyl-terminal repeat domain of RNA polymerase II at threonine 4 occurs at the 3' end of most human genes and is necessary for transcription elongation (Hintermair et al. 2012).
Wide species cross-reactivity is expected from Rabbit anti Human RNA pol II CTD (pThr4) based on sequence.
