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Mouse Anti-Human CD62E Monoclonal Antibody, Azide Free Clone B-S3
Mouse Anti-Human CD62E Monoclonal Antibody, Azide Free Clone B-S3
- 中文名称：
- Mouse Anti-Human CD62E Monoclonal Antibody, Azide Free Clone B-S3
- 英文名称：
- Mouse Anti-Human CD62E Monoclonal Antibody, Azide Free Clone B-S3
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA58570
- 规格：
- 0.2 mg|0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg
- 保存建议：
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Mouse IgG1 Kappa light chain
克隆号:[B-S3]
特异性:Recognizes the Endothelial Leucocyte Adhesion Molecule-1 (ELAM-1), E-selectin, a 97 kDa protein
纯度:N/A
形式：Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free.
浓度：N/A
- 说明书：
E-selectin (CD62E) is a 115 kDa glycoprotein, expressed only on endothelial cells after activation with interleukin-1 (IL-1), tumor necrosis factor-α (TNFα), or bacterial lipopolysaccharides. After stimulation of the endothelial cells, the newly synthesized E-selectin is rapidly detected, with maximum surface expression after 3-6 h and return to basal levels within 24 h. This rapid down-regulation, although poorly understood, has been explained by the release of a soluble form of E-selectin and the internalization of the molecule. This regulation of E-selectin expression could be crucial for controlling leukocyte accumulation in inflammatory responses. Several E-selectin ligands have been identified on leukocytes, but have not yet been cloned. Monoclonal antibodies (mAbs) specific for E selectin have been shown to inhibit leukocyte transmigration. It has been suggested that leukocyte binding to E-selectin on activated endothelium positively regulates CD11b (Mac-1) on leukocytes and induces increased adhesion by the ICAM-1 / Mac-1 interaction.
