-
Mouse Anti-Human CD141 Monoclonal Antibody, Azide Free Clone B-A35
Mouse Anti-Human CD141 Monoclonal Antibody, Azide Free Clone B-A35
- 中文名称：
- Mouse Anti-Human CD141 Monoclonal Antibody, Azide Free Clone B-A35
- 英文名称：
- Mouse Anti-Human CD141 Monoclonal Antibody, Azide Free Clone B-A35
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA58572
- 规格：
- 0.2 mg|0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg
- 保存建议：
- Store at +2-8°C. For longer storage, freeze aliquots.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- ELISA, FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Mouse IgG1 Kappa light chain
克隆号:[B-A35]
特异性:Recognises thrombomodulin (TM), a 105 kDa protein
纯度:Ion exchange chromatography
形式：Azide free
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
浓度：N/A
- 说明书：
CD141 , also known as Thrombomodulin or BDC-A is an transmembrane protein expressed predominantly on the surface of vascular endothelial cells, but also on other cell types such as macrophages, monocytes, subpopulation of myeloid dendritic cells and keratinocytes. Thrombomodulin is a type 1 membrane glycoprotein of 74kDa consisting on a single chain with 6 Epidermal Growth Factor (EGF)-like domains critical for Thrombin and proteine C binding, and four other domains (an N-terminal C-type lectin domain, a highly glycosylated serine/threonine-rich domain, a transmembrane segment, and a short C-terminal cytoplasmic tail. It acts as an important component in the anti-coagulation and fibrinolysis system : cofactor for active thrombin, the thrombomodulin-thrombin complex activates protein C to degrade coagulation factors, inhibiting coagulation and fibrinolysis.
When vascular endothelial cells injury occurs, proteolytic cleavage release multiple fragments of thrombomodulin in circulation, so it represents a good marker for endothelial cell damage in pathologies such as cardiovascular disease, acute coronary syndrome, pulmonary thromboembolism or severe hemorrhage. Thrombomodulin has been described as an anticoagulant effect protein, and its therapeutical potential for preventing deep vein thrombosis and its use in the treatment of disseminated intravascular coagulation is under demonstrated in preliminary data.
More recently, other biological effects beyond anticoagulation have been demonstrated such as an anti-inflammatory , cell adhesion and proliferation regulation It is also demonstrated that thrombomodulin may be able to suppress the metastatic capacity of tumor cells, and hence have a protective role in many types of malignancies.
