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ACE-2 (BSB-135)
ACE-2 (BSB-135)
- 中文名称：
- ACE-2 (BSB-135)
- 英文名称：
- ACE-2 (BSB-135)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59346
- 规格：
- 5 Slides|0.1 mL (Concentrate)|3 mL (RTU)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[BSB-135]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
ACE2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Angiotensin Converting Enzyme 2 is a dipeptidyl carboxydipeptidase active in the renin-angiotensin pathway, which helps regulate cardiovascular and renal functions. ACE2 is a secreted protein that cleaves angiotensin I (AngI) into angiotensin 1-9, and angiotensin II (AngII) into vasodilator angiotensin 1-7. ACE2 is expressed in the heart and kidney, where it may counteract vasoconstriction by inactivating Ang II. It is also found in the GI tract, lungs, and testis, in endothelial cells and less in vascular smooth muscle cells. ACE2 can contribute to tumor inhibition by inactivating AngII, which has been found to participate in tumor proliferation, angiogenesis, and metastasis.
ACE2 has shown inhibitory effects on lung, prostate, breast, and liver cancer through various signaling mechanisms, and its expression may be correlated with immune cell penetration into the tissue. ACE2 also functions as the main receptor for the spike glycoprotein of human coronaviruses HCoV-NL63, SARS-CoV and SARS-CoV-2.
