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TMPRSS2 (BSB-136)
TMPRSS2 (BSB-136)
- 中文名称：
- TMPRSS2 (BSB-136)
- 英文名称：
- TMPRSS2 (BSB-136)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59347
- 规格：
- 5 Slides|0.1 mL (Concentrate)|3 mL (RTU)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[BSB-136]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
TMPRSS2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Transmembrane Serine Protease 2 is part of the serine protease family, which is active in many physiological and pathological pathways. TMPRSS2 is a 492 amino acid protein, containing a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain, and a protease domain. It is upregulated by androgen hormones particularly in the prostate, where it may contribute to inflammation by activating PAR2 and prostate cancer through somatic rearrangement. TMPRSS2 antibody is also expressed in the GI tract, stomach, kidney and in the lung epithelium, where it may cleave epithelial sodium channels. The TMPRSS2-ERG fusion pair is a common somatic gene rearrangement occurring in about 50% of primary prostate cancers.
TMPRSS2 antibody positive tumors may be at higher risk for metastasis and influence from hormones, with a different androgen metabolism and higher insulin signaling than negative tumors. The protease domain also proteolytically cleaves and activates viral envelope glycoproteins, facilitating the cellular entry of human influenza and coronaviruses such as SARS-CoV-2.
