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CD147 (BSB-137)
CD147 (BSB-137)
- 中文名称：
- CD147 (BSB-137)
- 英文名称：
- CD147 (BSB-137)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59348
- 规格：
- 5 Slides|0.1 mL (Concentrate)|3 mL (RTU)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[BSB-137]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
CD147 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
CD147 is a transmembrane glycoprotein also known as Basigin or EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), participating in tumor development and viral entry pathways. CD147 is a member of the immunoglobulin superfamily, upregulated in asthmatic, diabetic, and other inflammatory pathways where it induces expression of Matrix Metalloproteinase 1 and 9. CD147 and its effectors are induced by high-glucose concentration in monocytes and promote their migration. CD147 also participates in fibroblast differentiation through TGF-b1-induced signaling pathways, and is a marker of undifferentiated human embryonic stem cells.
CD147 antibody has been found to be upregulated in cancer stem cells, resulting in increased metabolism through lactic acid export, increased production of hyaluronan, inhibiting apoptosis, and acting as a main upstream stimulator of matrix metalloproteinases. In clinical studies, CD147 has been associated with larger tumors, deeper invasion, and more lymphocytes. CD147 also facilitates the entry of malaria parasite Plasmodium falciparum into red blood cells, and the entry of coronaviruses into human cells by binding the spike glycoprotein, functioning as the second receptor for SARS-CoV-2 and potential participant in pulmonary fibrosis.
