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Annexin VII (EP367)
Annexin VII (EP367)
- 中文名称：
- Annexin VII (EP367)
- 英文名称：
- Annexin VII (EP367)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59353
- 规格：
- 3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)|15 mL (RTU)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[EP367]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Anti-Annexin VII is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Annexin VII (or Annexin A7) is a Ca2+ -dependent and phospholipid-binding protein. It is encoded by the ANX7 gene, which is located in human chromosome 10q21. It is a member of the annexin protein family, which regulates various endomembrane processes including vesicle fusion, segregation, and compartmentalization and is implicated in plasma membrane repair mechanisms.
Studies suggest that ANX7 is a tumor suppressor gene and it was found that Annexin VII is associated with several types of cancers, such as Prostate, Breast, Liver, and Gastric cancer. IHC analysis showed that a low or the loss of expression of Annexin VII antibody correlates with Prostate cancer progression. On the contrary, high levels of Annexin VII expression were found in Metastatic Breast Tumors and that HER2-Negative patients suffer increased risk of death when ANX7 expression levels are elevated. Another study found that ANX7 predominantly shows low expression in other cancer types, such as Colon Adenocarcinoma or Bladder Transitional Cell Carcinoma. A study identified the prognostic impact of ANXA7 in Prostate Cancer using tissue microarrays, identified ANXA7 as a new prognostic factor and indicated a bimodal correlation to tumor progression. Another study concluded that Annexin A7 expression was able to inhibit HCC lymph node metastasis, whereas knockdown of Annexin A7 expression significantly induced HCC metastasis to local lymph nodes.
