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Factor H/Complement Factor H (BSB-164)
Factor H/Complement Factor H (BSB-164)
- 中文名称：
- Factor H/Complement Factor H (BSB-164)
- 英文名称：
- Factor H/Complement Factor H (BSB-164)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59367
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[BSB-164]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Factor H is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Factor H or Complement Factor H (CFH), is the major soluble inhibitor of complement, where its binding to self markers (i.e. particular glycan structures) prevents complement activation and amplification on host surfaces. Mutations and polymorphisms that affect recognition of self markers by Factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical hemolytic uremic syndrome. In addition, pathogens and cancer cells can hijack Factor H to evade the immune response.
Lung, Ovarian, Glial and Colon Cancer cells show enhanced expression and surface binding of soluble regulators, including Factor H. Factor H antibody has been shown to be expressed by human Breast Cancer cells, which correlates with the presence of immunosuppressive macrophages, Breast Cancer recurrence and severity of the disease. Lung cancer cells may develop a protective mechanism against complement attack by expressing and binding Factor H to their cell membranes. Additionally, it has been demonstrated that Factor H is upregulated by constitutive activation of STAT4, which is accounted for by SOCS silencing in Lung Cancer cells. Several studies have also suggested the importance of Factor H in the protection of tumor cells against complement activation. The importance of Factor H antibody expression for the protection of cancer cells in vivo will help to elucidate the mechanisms used by tumor cells to avoid complement activity and assist in the design of more efficient complement-mediated immunotherapies.
