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IDH1 R132H (RBT-IDH1)
IDH1 R132H (RBT-IDH1)
- 中文名称：
- IDH1 R132H (RBT-IDH1)
- 英文名称：
- IDH1 R132H (RBT-IDH1)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59376
- 规格：
- 3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)|15 mL (RTU)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RBT-IDH1]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
IDH1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
IDH1 is an isocitrate dehydrogenase isozymes and encoded by the gene IDH1. IDH1 is involved in the citric acid cycle during glucose metabolism and catalyzes the oxidation of isocitrate to ?-ketoglutarate and reduction of NADP+ to NADPH. Both ?-ketoglutarate and NADPH play a role in protecting cells from oxidative stress and mitigating oxidative damage. Mutation in residue 132 of IDH1 results in loss of enzymatic function, build up of 2-hydroxyglutarate, and change in histone and DNA methylation.
Mutation of IDH1 is implicated in metaphyseal chondromatosis with aciduria as well as diffused gliomas and a number of neoplasms such as acute myeloid leukemia, acute lymphocytic leukemia, myelofibrosis, intrahepatic cholangiocarcinoma, melanoma, chondroid tumors, and certain rare forms of colonic and prostate carcinomas. However studies have shown that IDH1 mutation is not a direct trigger of oncogenesis, but strongly associated with other tumor-promoting mutations. Screening for IDH1 mutation can provide valuable information on identification and prognosis of glioma. Glioma with IDH1 mutation tend to be less aggressive than glioma without IDH1 mutation.
