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IFN-Alpha (BSB-158)
IFN-Alpha (BSB-158)
- 中文名称：
- IFN-Alpha (BSB-158)
- 英文名称：
- IFN-Alpha (BSB-158)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59377
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2b
克隆号:[BSB-158]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
IFN-a is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Type I interferons are a large subgroup of interferon proteins that help regulate the immune system by binding to IFN-? receptors. IFN-? (IFN-a) is produced mainly by plasmacytoid dendritic cells and involved in innate immunity against viral infections. Binding of IFN-? to its receptor leads to downstream signalling and expression of numerous different IFN-stimulated genes. These genes encode antiviral proteins that directly inhibit viral replication as well as modulate immune function.
Studies have shown IFN-a strongly modulates innate and adaptive immune responses in the host by enhancing the proliferation, cytotoxicity and IFN-gamma secretion of NK cells, as well as acting as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus which causes fever. It does this by binding to opioid receptors and eliciting the release of prostaglandin-E2. IFN-a can also interact with the u-opioid receptor to act as an analgesic. Additionally, recent studies have shown that Type 1 IFNs stimulate secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with compromised effector T cell generation and trafficking. Type 1 IFNs also induce MHC class 1 upregulation on tumor cells which can enhance antitumor CD8 T cell effector response in the tumor microenvironment.
