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MNDA (BSB-157)
MNDA (BSB-157)
- 中文名称：
- MNDA (BSB-157)
- 英文名称：
- MNDA (BSB-157)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59382
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[BSB-157]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
MNDA is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Myeloid cell Nuclear Differentiation Antigen (MNDA) is present in granulocytes and monocytes (myeloid and B cells), found in the marginal zones of germinal centers in tonsil, lymph node, spleen. MNDA is a highly basic protein from 1q22, and is part of the family of nuclear proteins expressed in reaction to interferons. MNDA contains a Pyrin 'death domain' used in self-association and is suggested to induce or help prevent different programmed cell death pathways in hematopoietic cells.
MNDA antibody expression is studied mainly in leukemias and lymphomas. MNDA antibody is a marker to distinguish Nodal Marginal Zone Lymphoma from Follicular Lymphoma, and has been shown to be downregulated in Myelodysplastic Syndrome, a precursor for Leukemia. MNDA overexpression in Osteosarcoma induces apoptosis and protects patients from metastasis, and expression in Chronic Lymphocytic Leukemia indicates the degradation of anti-apoptotic mRNA, allowing cells suffering genotoxic stress to undergo apoptosis.
