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MTAP (RBT-MTAP)
MTAP (RBT-MTAP)
- 中文名称：
- MTAP (RBT-MTAP)
- 英文名称：
- MTAP (RBT-MTAP)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59383
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RBT-MTAP]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
MTAP is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
The S-methyl-5?-thioadenosine phosphorylase (MTAP) metabolizes methylthioadenosine (MTA), a byproduct of polyamine synthesis and regulator of protein methylation, to salvage adenine and methionine residues for reuse in many pathways affecting cell proliferation, signaling, and apoptosis. The MTAP gene, located at 9p12.3, is co-deleted with CDKN2A (encodes p16 tumor-suppressor) in several types of cancer and is abundant in all normal tissues but is deficient in various tumors.
IHC has been found to be an accurate and useful test method for detecting MTAP deficiency in NSCLC, and the frequency of MTAP deficiency was found to be relatively high. Accumulated MTA can upregulate transcription factors, activate ERK pathways in Melanoma and MAPK in Liver Cancer causing invasive and metastasizing tumors, and disrupt function of secretory cells in tissues like the prostate. Disrupted DNA methylation affects epigenetic factors and can lead to dedifferentiated stem-like cancer cells in Glioblastoma, although these cells can suffer purine starvation without a functioning salvage pathway. Overexpression of MTAP is also associated with increased proliferation and epithelial-to-mesenchymal transition in Colorectal Carcinoma.
A study has found that a combination of MTAP antibody or BAP1 antibody loss detected by IHC can likely detect malignant pleural mesothelioma (MPM) with good sensitivity and 100% specificity, and serve as a useful ancillary IHC for discriminating MPM from reactive mesothelial hyperplasia (RMH).
