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MUSshi 2 (RM422)
MUSshi 2 (RM422)
- 中文名称：
- MUSshi 2 (RM422)
- 英文名称：
- MUSshi 2 (RM422)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59384
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RM422]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Musashi 2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Musashi-2 (MSI2) is an RNA-binding protein present in the cytoplasm of hematopoietic, neuronal progenitor, and stem cells. Musashi proteins have an RNA-recognition motif used to bind and stabilize mRNA in stem cell populations. MSI2 is also present in blood cells, astrocytes, and the development of reproductive cells in spermatogenesis and oogenesis.
Musashi 2 antibody can indicate the presence of stem cells in tumors of Colorectal, Lung, and Pancreatic Cancers, and in Glioblastoma, Leukemias, and xenografts, where it supports proliferation and prevents apoptosis. It's RNA-binding ability is increased in Leukemia cells over normal hematopoietic stem cells, and it's expression in Acute Myeloid Leukemia is associated with poor prognosis. MSI2 also has a role in promoting epithelial-to-mesenchymal transition, such as in Hepatocellular Carcinoma. MSI2-HOXA9 and other fusions/transformations are rare but MSI2 over-expression is found in almost all hematological disorders, and can be up-regulated further resulting in worse prognosis. Studies comparing normal cervical tissues have found that the expression of Musashi 2 is increased in cervical cancer tissues and may act as a prognostic biomarker in patients with cervical cancer. MSI2 has been found to be significantly upregulated in bladder cancer cells and tissues compared with normal bladder urothelial cells and tissues. IHC analysis has revealed high expression of Musashi 2 in bladder cancer specimens. It has been demonstrated that MSI2 can induce bladder cancer cell migration and invasion by activating the JAK2/STAT3 pathway, and may be a valuable prognostic biomarker for bladder cancer patients.
