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pan-TRK (RM423)
pan-TRK (RM423)
- 中文名称：
- pan-TRK (RM423)
- 英文名称：
- pan-TRK (RM423)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59385
- 规格：
- 3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)|15 mL (RTU)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RM423]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
pan-TRK is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Neurotrophic tyrosine kinase (NTRK) proto-oncogene family codes for proteins Trk A, Trk B, and Trk C, which participate in pathways of neuron cell growth, differentiation, signaling, and survival. The transmembrane neurotrophic receptors are activated by neurotrophins (Nerve Growth Factor, Brain-Derived Growth Factor, and neurotrophins 3/4/5) and in turn the TRKs activate MAPK, AKT, and Phospholipase C pathways. Non-fusion alterations in NTRK have been found in 14% of tested cancers. panTRK staining can be cytoplasmic, nuclear (as in NTRK-ETV6 and NTRK-LMNA fusions), or membranous (in NTRK-TMP3/4) depending on the fusion pair.
NTRK fusions result in NTRK3-ETV6 pairs in 90% of cases, most commonly found in Carcinomas and Sarcomas of the Mammary and Salivary Secretory Glands. NTRK gene fusions are also found in Brain primary tumors and metastases, Lung, Breast, Papillary Thyroid Carcinoma, Colorectal and Pancreatic cancer. NTRK mesenchymal tumors have multiple morphological features and coexpression of S100, CD34, and panTRK.
