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PAX-7 (BSB-145)
PAX-7 (BSB-145)
- 中文名称：
- PAX-7 (BSB-145)
- 英文名称：
- PAX-7 (BSB-145)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59386
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2a
克隆号:[BSB-145]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
PAX-7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
PAX-7 or Paired Box Gene 7 is a transcription factor coded by a gene on locus 1p36, which can fuse with Forkhead Domain Region (FKHR). PAX-7 protein is involved in developmental pathways in neural tube and mesencephalon formation, muscle cell development, and oxidative stress sensitivity. PAX-7 regulates neural cell adhesion molecules and is expressed in proliferating myoblasts, but it is down-regulated after playing its role in cell differentiation toward muscle-derived specification.
PAX-7 is restricted to muscle satellite and myogenic precursor cells in adults, although it is upregulated in embryonal (ERMS) and alveolar rhabdomyosarcoma (ARMS) and could suggest a de-differentiated cell type when overexpressed in these tumors. Recent studies suggested that PAX-7 antibody is a novel marker, because it was expressed consistently in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. PAX-7 antibody was found expressed in 90% of Ewing sarcomas (90%), mainly in a diffuse and strong manner. Although NKX2-2 showed similar sensitivity, PAX-7 showed more extensive and strong reactivity. ARMS differs from ERMS by virtue of its occurrence in older patients, distinctive pseudoalveolar pattern, usual absence of strap cells, and strong myogenin rather than MyoD1 expression. Identification of a PAX3 or PAX-7/FKHR fusion gene may be necessary for the confident distinction of ARMS from the most primitive forms of ERMS.
