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SF-1/Steroidogenic Factor 1 (BSB-149)
SF-1/Steroidogenic Factor 1 (BSB-149)
- 中文名称：
- SF-1/Steroidogenic Factor 1 (BSB-149)
- 英文名称：
- SF-1/Steroidogenic Factor 1 (BSB-149)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59389
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2a
克隆号:[BSB-149]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Anti-SF-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
The Steroidogenic Factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling activity of genes related to the reproductive glands or gonads and adrenal glands. This protein is encoded by the NR5A1 gene. SF-1 expression is localized to adult steroidogenic tissues correlating with known expression profiles of steroid hydroxylases. Using in situ hybridization with SF-1 cRNA-specific probes detected gene transcripts in adrenocortical cells, Leydig cells, and ovarian theca and granulosa cells. SF-1 specific antibody studies confirmed the expression profile of SF-1 in rats and humans corresponding to sites of transcript detection.
SF-1 antibody has been found to be a highly valuable IHC marker to determine the adrenocortical origin of an adrenal mass with high sensitivity and specificity. In addition, SF-1 expression is of stage-independent prognostic value in patients with adrenocortical carcinoma. Other SF-1 pathologies include adrenal failure (mutations in the SF-1 DNA-binding interface), adrenal or ovarian insufficiency and gonadal dysgenesis (heterozygous mutations), endometriosis (promoter hypomethylation), and male infertility (mutations in the hinge region of the protein). For the differential identification with endometrioid tumors and carcinoid of the ovary, SF-1 antibody is a sensitive and specific IHC marker for Sertoli cell tumor and that SF-1 is testally comparable with other good sex cord-stromal markers.
