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Surfactant protein D/SP-D (BSB-162)
Surfactant protein D/SP-D (BSB-162)
- 中文名称：
- Surfactant protein D/SP-D (BSB-162)
- 英文名称：
- Surfactant protein D/SP-D (BSB-162)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59390
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[BSB-162]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
Surfactant Protein is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Surfactant protein D, also known as SFTPD or SP-D, is a protein encoded by the SFTPD gene. Pulmonary surfactants are essential to proper respiratory structure and function, consisting of ~90% lipids (mostly phospholipids) and 8-10% surfactant-associated proteins. SP-D is a pattern-recognition molecule in the collectin (collagen-containing C-type lectin) family. In the lungs, it is an opsonin that can agglutinate a range of microbes and enhance their clearance via phagocytosis and super-oxidative burst. It can interfere with allergen-IgE interaction and suppress basophil and mast cell activation.
Other surfactant proteins like SP-B and SP-C showed strong immunohistochemical expression in Lung Hyperplasias and Adenomas, suggesting that SP-B and SP-C are related to lung tumorigenesis. SP-D is likely an innate immune surveillance molecule against tumor development. SP-D suppresses Lung Cancer progression via interference with epidermal growth factor signaling, and a truncated recombinant human SP-D may induce apoptosis in Pancreatic Adenocarcinoma via Fas-mediated pathway in a p53-independent manner. Studies Have found low expression of Surfactant protein D antibody expression in Lung, Gastric, and Breast cancers and high expression in different stages and grades of Ovarian cancer. Surfactant protein D antibody expression could be associated with a favorable prognosis in Lung Cancer but unfavorable in non-pulmonary sites such as Gastric, Breast, and Ovarian cancers. SP-D detected in circulating tumor cells of Ovarian Cancer patients suggests SP-D can also be used as a potential biomarker.
The purified Spike protein of SARS-CoV-2 bound to Vero but not 293T cells and was itself recognized by SP-D, in the lung alveoli. It suggests that SARS-CoV interacts with innate immune mechanisms in the lung through its S-protein and regulates pulmonary inflammation.
