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TDP-43/TARDBP (BSB-166)
TDP-43/TARDBP (BSB-166)
- 中文名称：
- TDP-43/TARDBP (BSB-166)
- 英文名称：
- TDP-43/TARDBP (BSB-166)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59413
- 规格：
- 5 Slides|3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Rat, Horse, Dog, Bovine
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2a
克隆号:[BSB-166]
特异性:N/A
纯度:N/A
形式：TDP-43 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections, and cell preparations.
Transactive Response DNA binding protein 43 (TARDBP) is an RNA and DNA binding protein in the heterogenous nuclear ribonucleoprotein (hnRNP) family, where it regulates RNA associated with glucose and lipid metabolism. TARDBP has been found to interact with miRNAs (though Drosha and Dicer complexes), mRNAs, long ncRNAs, snoRNAs and rRNAs, affecting their transcription, pre-mRNA splicing, RNA transport and translational regulation.
TARDBP is associated with several neurodegenerative conditions (amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)) and metabolic regulation in cancer cells. TARDBP regulation of miRNAs has both tumor supporting and suppressive roles. Upregulation of TARDBP can lead to continued autophagy for survival and suppression of apoptosis pathways, promoting cancer cell survival under conditions of nutrient stress, as was seen in a study of glioblastomas. TARDBP and its targeted miRNAs have been associated with increased cell growth and migration in hepatocellular and lung cancers, but also with tumor inhibition in rhabdomyosarcomas through miRNA miR- 500a- 3p. TARDBP may also influence the function and targets of MiR-152, and miRNA associated with hepatocellular carcinoma, endometrial, gastric, and ovarian cancers.
