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Rabbit anti TGF beta Receptor II Polyclonal Antibody
Rabbit anti TGF beta Receptor II Polyclonal Antibody
- 中文名称：
- Rabbit anti TGF beta Receptor II Polyclonal Antibody
- 英文名称：
- Rabbit anti TGF beta Receptor II Polyclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71300
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- The antibodies are stable for 12 months from date of receipt when stored at –20°C to –70°C. The antibodies can be stored at 2°C-8°C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- WB (Western Blot), IP (Immunoprecipitation), IHC (Immunohistochemistry), ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:This antibody reacts with human TGF-beta Receptor II. The other species are not tested.
纯度:Purified by Epitope Affinity Purification
形式：Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
浓度：N/A
- 说明书：
Background: Transforming growth factor ? isoforms (TGF-β1, 2, 3) play vital roles in regulating cellular growth and differentiation, and they signal through a highly restricted subset of receptors known as TGF-β type I receptor (TβR-I) and TGF-β type II receptor (TβR-II). TGF-β's specificity for TβR-I has been proposed to arise from its pre-helix extension, a five-residue loop that binds in the cleft between TGF-β and TβR-II. TGF-β binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, which requires both its kinase activity and association with another TGF betabinding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. Mutations in TβR-I and TβR-II gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS)
