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Rat Anti Heat Shock Factor 1 Monoclonal Antibody
Rat Anti Heat Shock Factor 1 Monoclonal Antibody
- 中文名称：
- Rat Anti Heat Shock Factor 1 Monoclonal Antibody
- 英文名称：
- Rat Anti Heat Shock Factor 1 Monoclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71351
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 to 8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rat
- 反应种属：
- Human, Mouse, Rat
- 应用：
- IHC (Immunohistochemistry), IP (Immunoprecipitation), WB (Western Blot), ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1k
克隆号:N/A
特异性:This antibody recognizes GST-fusion proteins.
纯度:Purified by Affinity Chromatography according to the isotyping.
形式：Supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
浓度：N/A
- 说明书：
Heat-shock factor 1 (HSF1) is the master transcriptional regulator to respond to the cellular stress signals, such as heat, heavy metals, and oxidative reagents and a wide variety of other stressors. It binds to heat shock response elements (HSEs) in the upstream region of heat shock gene and activates their transcription. Some laboratories have reported that the constitutive, non-DNA binding, monomeric form of inactive HSF1 is located in the cytoplasm. Upon activation, HSF1 is trimerized and is localized in nucleus where it binds DNA. The increased HSF1 which is associated with reduced breast cancer survival may imply that HSF1 should be evaluated prospectively as an independent prognostic indicator in ER-positive breast cancer. HSF1 may ultimately be a useful therapeutic target in cancer.
