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Mouse anti Claudin 5 Monoclonal Antibody
Mouse anti Claudin 5 Monoclonal Antibody
- 中文名称：
- Mouse anti Claudin 5 Monoclonal Antibody
- 英文名称：
- Mouse anti Claudin 5 Monoclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71368
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- The antibodies are stable for 24 months from date of receipt when stored at –20°C to –70°C. The antibodies can be stored at 2°C-8°C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- IP (Immunoprecipitation), ELISA, WB (Western Blot), IHC (Immunohistochemistry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:[4C3C2]
特异性:This antibody recognizes human Claudin 5 protein. The other species are not tested.
纯度:Protein A-Affinity Chromatography according to Isotyping
形式：Supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
浓度：N/A
- 说明书：
Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. CLDN5 affects lncRNAs acting as ceRNA dynamics contributing to regulating blood brain barrier permeability in tumor brain metastasis. Among other tissues, Claudin-5 was observed to localize to cardiomyocytes, endothelial cells, and a subset of fibroblasts in non-failing human heart sections. It is transcriptionally downregulated resulting in dramatically reduced protein levels in human heart failure. It was recently shown that strong claudin 5 expression is a poor prognostic sign in pancreatic adenocarcinoma.
