Anti-Aquaporin 4 [C9401]-Anti-Aquaporin 4 [C9401]-一抗检测抗体

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: Anti-Aquaporin 4 [C9401]

Anti-Aquaporin 4 [C9401]

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中文名称：: Anti-Aquaporin 4 [C9401]

英文名称：: Anti-Aquaporin 4 [C9401]

品牌：: AAA Biotech

品牌介绍：: AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。

货号：: AAA72337

规格：: 0.2 mg|2x0.2 mg|3x0.2 mg|4x0.2 mg|5x0.2 mg

保存建议：: Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.

货期：: 6-8周

来源宿主：: N/A

反应种属：: Human

应用：: IA (Inhibition Assay), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry), ELISA

免责声明：: *本产品仅供科研实验使用，不得用于临床诊断。*

其他：: 克隆性:N/A
同型:Rabbit IgG kappa
克隆号:[C9401]
特异性:This antibody recognizes and binds extracellular domains of both the M1 and M23 isoforms of human aquaporin 4 (AQP4), but not mouse aquaporin 4. AQP4 is a water channel expressed on astrocytes throughout the CNS and in skeletal muscle and some epithelial cells outside of the CNS. It plays an important role in brain water homeostasis and in glymphatic solute transport. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) that is associated with demyelination and neurological deficits in optic nerve, spinal cord and brainstem. Most NMOSD patients are seropositive for IgG autoantibodies (NMO-IgG) directed against extracellular epitopes of aquaporin-4 (AQP4). Prevention of the binding of NMO-IgG, therefore, may alleviate the disease.
纯度:Purified. Protein A affinity purified
形式：PBS with 0.02% Proclin 300.
浓度：1mg/ml

说明书：

The original antibody was generated by immunizing an aquaporin 4 knock out mice with human AQP4 as an immunogen expressed on the surface of baculovirus.
Describes the generation of antibodies against extracellular domain of AQP4 and explores the therapeutic application of this antibody in the treatment of neuromyelitis optica patients.
This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.

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