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Lipopolysaccharide Core, mAb WN1 222-5
Lipopolysaccharide Core, mAb WN1 222-5
- 中文名称：
- Lipopolysaccharide Core, mAb WN1 222-5
- 英文名称：
- Lipopolysaccharide Core, mAb WN1 222-5
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77825
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Lipopolysaccharide
- 应用：
- WB (Western Blot), IHC (Immunohistochemistry), IA (Immunoassay), FA (Functional Assay)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Mouse IgG2a
克隆号:[222-5]
特异性:N/A
纯度:N/A
形式：Quantities >500 ug will be send without preservative and carrier free. Quantities <500 ug will be send with preservative and carrier. exact formulation can be found on the datasheet.
浓度：N/A
- 说明书：
Meet the remarkable mouse monoclonal antibody clone WN1 222-5, a precision tool in the realm of immunology. This antibody has a unique ability - it targets the core region of lipopolysaccharide (LPS) with extraordinary accuracy while showing no reactivity to free lipid A, Rd2, or smaller LPS variants. Let's delve into the intriguing world of LPS and its significance.
Lipopolysaccharide (LPS) is a key element of Gram-negative bacteria, infamous for causing infections via strains like E. coli and Salmonella. Comprising three parts—lipid A, core oligosaccharide, and O-polysaccharide—LPS forms the endotoxin essential to bacterial survival and virulence. Understanding the structure of LPS, especially the toxic lipid A and the variable O-polysaccharide, is critical for developing targeted antibacterial treatments.
Humans and vertebrates encounter LPS through exposure to enterobacteria, which release small amounts of endotoxins as they grow. LPS is heat-stable and can cause watery diarrhea and inflammation upon interacting with the digestive tract.
Additionally, LPS also plays a role in conditions like necrotizing enterocolitis (NEC), primarily affecting newborns. If LPS enters the bloodstream, it binds to host cells, triggering complex responses and, in severe cases, organ failure (septic shock).
Furthermore, LPS inhibits Interleukin-6 (IL-6), which presents a strategic method for fine-tuning the body's immune response. As a central cytokine, IL-6 is instrumental in both inflammation control and muscle function, serving a dual role in defense mechanisms and metabolism. Targeting IL-6 inhibition offers a pathway to mitigate conditions characterized by chronic inflammation, such as autoimmune disorders, metabolic syndromes, and certain types of cancers.
