-
Mouse Monoclonal Antibody to Human Interleukin-15 (IL-15)
Mouse Monoclonal Antibody to Human Interleukin-15 (IL-15)
- 中文名称：
- Mouse Monoclonal Antibody to Human Interleukin-15 (IL-15)
- 英文名称：
- Mouse Monoclonal Antibody to Human Interleukin-15 (IL-15)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77973
- 规格：
- 0.1 mg|0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg
- 保存建议：
- Store at -20°C
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human, others not tested
- 应用：
- ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1 Kappa
克隆号:[B1H6]
特异性:Reactive with recombinant human IL-15.
纯度:Protein G Affinity Purified
形式：Lyophilized from a solution in 0.01M PBS, pH 7.0
浓度：N/A
- 说明书：
Interleukin (IL)-15 is an inflammatory cytokine that can induce tumor-necrosis factor-alpha, IL-1beta and inflammatory chemokines. It acts on T cells and natural killer cells through receptors on these cells. IL-15 and IL-2 share common receptor alpha and gamma units (IL-15/IL-2Rbetagammac) and thus some overlapping functions in stimulating T-cell proliferation and cytokine secretion. However, both cytokines have its own specific receptor alpha(IL-15Ralpha or IL-2Ralpha) that links to distinct signaling pathways. For example, IL-15 can inhibit self-tolerance mediated by IL-2 mediated activation-induced T cell death, and promote CD8+ memory T-cell survival. Increased IL-15 expression has been reported in patients with psoriasis and other inflammatory autoimmune diseases. IL-15 exists as soluble form, as well as membrane-bound form in which it could be directly bound to the cellular membrane or presented by IL-15Ralpha receptor. The main mechanism of IL-15 signaling is trans-presentation which is initiated by IL-15 binding to IL-15Ralpha. The IL-15/IL-15Ralpha complex subsequently presents IL-15 to surrounding cells bearing IL-15Rbetagammac complex on their cell surface. Recent research showed that combined activation with IL-12, IL-15, and IL-18 can induce memory-like natural killer (NK) cells that live longer and exhibit enhanced functionality when they encounter a secondary stimulation. The progress has led to increased interest in using IL-15 for cancer therapy.
