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CXCR3 Antibody (Center) Blocking peptide
CXCR3 Antibody (Center) Blocking peptide
- 中文名称：
- CXCR3 Antibody (Center) Blocking peptide
- 英文名称：
- CXCR3 Antibody (Center) Blocking peptide
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA290749
- 规格：
- 0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg|5x0.5 mg
- 保存建议：
- Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
This gene encodes a G protein-coupled receptor withselectivity for three chemokines, termed IP10(interferon-g-inducible 10 kDa protein), Mig (monokine induced byinterferon-g) and I-TAC (interferon-inducible T cella-chemoattractant). IP10, Mig and I-TAC belong to the structuralsubfamily of CXC chemokines, in which a single amino acid residueseparates the first two of four highly conserved Cys residues.Binding of chemokines to this protein induces cellular responsesthat are involved in leukocyte traffic, most notably integrinactivation, cytoskeletal changes and chemotactic migration.Inhibition by Bordetella pertussis toxin suggests thatheterotrimeric G protein of the Gi-subclass couple to this protein.Signal transduction has not been further analyzed but may includethe same enzymes that were identified in the signaling cascadeinduced by other chemokine receptors. As a consequence ofchemokine-induced cellular desensitization(phosphorylation-dependent receptor internalization), cellularresponses are typically rapid and short in duration. Cellularresponsiveness is restored after dephosphorylation of intracellularreceptors and subsequent recycling to the cell surface. This geneis prominently expressed in in vitro cultured effector/memory Tcells, and in T cells present in many types of inflamed tissues. Inaddition, IP10, Mig and I-TAC are commonly produced by local cellsin inflammatory lesion, suggesting th at this gene and itschemokines participate in the recruitment of inflammatory cells.Therefore, this protein is a target for the development of smallmolecular weight antagonists, which may be used in the treatment ofdiverse inflammatory diseases. Multiple transcript variantsencoding different isoforms have been found for this gene
